منابع مشابه
Predicting aberrant CpG island methylation.
Epigenetic silencing associated with aberrant methylation of promoter region CpG islands is one mechanism leading to loss of tumor suppressor function in human cancer. Profiling of CpG island methylation indicates that some genes are more frequently methylated than others, and that each tumor type is associated with a unique set of methylated genes. However, little is known about why certain ge...
متن کاملMETHYLATION OF ThE ANDROGEN RECEPTOR CPG ISLAND
Survivinis a memberofthe inhibitor ofapoptosis protein (IAP)family. WeInvestigated the antiapoptotic mechanism ofSurvivin, as well as its expressionIn 60 human tumor cell lines used for the National Cancer lontitute's anticancer drag screening program, In cotransfection experhnents, cell deathInduced by Bax or Faa (CD 95) was partially inhibited (mean ±SD,65%±8%)bySurv...
متن کاملAberrant methylation of the Cyclooxygenase 2 CpG island in colorectal tumors.
Cyclooxygenases (COXs) are key enzymes that convert arachidonic acid to prostaglandins. Overexpression of one of the COX isozymes, COX2, has been shown to play an important role in colorectal cancer progression. Recently, however, low expression of COX2 has been reported in a subset of colorectal and gastric cancers. Aberrant CpG island methylation and associated transcriptional silencing are c...
متن کاملAberrant methylation in gastric cancer associated with the CpG island methylator phenotype.
Aberrant methylation of 5' CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in cancer. In colorectal cancer, a group of tumors is characterized by a hypermethylator phenotype termed CpG island methylator phenotype (CIMP), which includes methylation of such genes as p16 and hMLH1. To study whether CIMP is present in gastric cancer, the methylation st...
متن کاملCpG Island Methylator Phenotype Aberrant Methylation in Gastric Cancer Associated with the Updated Version
Aberrant methylation of 5* CpG islands is thought to play an important role in the inactivation of tumor suppressor genes in cancer. In colorectal cancer, a group of tumors is characterized by a hypermethylator phenotype termed CpG island methylator phenotype (CIMP), which includes methylation of such genes as p16 and hMLH1. To study whether CIMP is present in gastric cancer, the methylation st...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2003
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.2037852100